| Pair Name | Platycodin D, Histone deacetylase inhibitor | ||
| Phytochemical Name | Platycodin D (PubChem CID: 162859 ) | ||
| Anticancer drug Name | Histone deacetylase inhibitor (PubChem CID: 10095659 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Platycodin D, Histone deacetylase inhibitor | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | MAPK1 | hsa5594 |
| Down-regulation | Phosphorylation | CFL1 | hsa1072 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Expression | CYCS | hsa54205 | |
| In Vitro Model | HA22T/VGH | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_7046 |
| HDACi-R | HDACi-R cell line was established from HA22T cells as described previously | Homo sapiens (Human) | N.A. | |
| Result | Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation | |||
| No. | Title | Href |
|---|---|---|
| 1 | Platycodin D reverses histone deacetylase inhibitor resistance in hepatocellular carcinoma cells by repressing ERK1/2-mediated cofilin-1 phosphorylation. Phytomedicine. 2021 Feb;82:153442. doi: 10.1016/j.phymed.2020.153442. | Click |
